Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.

dc.creatorNoronha, Almério Libório Lopes de
dc.creatorBafica, Andre Luiz Barbosa
dc.creatorNogueira, Lucas L
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.date2014-03-13T14:01:44Z
dc.date2014-03-13T14:01:44Z
dc.date2008
dc.date.accessioned2023-09-26T21:39:30Z
dc.date.available2023-09-26T21:39:30Z
dc.identifierNORONHA, A. L. L. de Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathology, Research and Practice, v. 204, p. 155–161, 2008.
dc.identifier0344-0338
dc.identifier10.1016/j.prp.2007.10.008
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7402
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873147
dc.descriptionTuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectMycobacterium tuberculosis
dc.subjectAutopsy
dc.subjectGranuloma
dc.subjectHIV
dc.subjectTNF
dc.subjectGranuloma do Sistema Respiratório/imunologia
dc.subjectInfecções por HIV/complicações
dc.subjectPulmão/imunologia
dc.subjectTuberculose Pulmonar/complicações
dc.subjectFator de Necrose Tumoral alfa/biossíntese
dc.subjectInfecções Oportunistas Relacionadas com a AIDS/imunologia
dc.subjectInfecções Oportunistas Relacionadas com a AIDS/patologia
dc.subjectGranuloma do Sistema Respiratório/microbiologia
dc.subjectGranuloma do Sistema Respiratório/patologia
dc.subjectInfecções Oportunistas Relacionadas com a AIDS/imunologia
dc.subjectInfecções por HIV/patologia
dc.subjectHIV-I
dc.subjectHumanos
dc.subjectPulmão/microbiologia
dc.subjectPulmão/patologia
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculose Pulmonar/imunologia
dc.subjectTuberculose Pulmonar/patologia
dc.titleLung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
dc.typeArticle


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