Article
Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts.
Registro en:
SANTOS, L. C. et al. Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. Journal of Molecular Histology, v. 38, n. 3, p. 201-205, 2007.
1567-2379
10.1007/s10735-007-9088-3
Autor
Santos, Luciano Cincurá Silva
Ramos, Eduardo Antônio Gonçalves
Gurgel, Clarissa Araújo Silva
Santana, Edmar José Borges de
Santos, Jean Nunes dos
Resumen
Objective Dental granulomas (DGs) and radicular cysts
(RCs) are chronic periapical lesions frequently involving
the jaws. Langerhans cells (LCs) are dendritic cells
responsible for the presentation of antigens to T lymphocytes.
This study examined the expression of LCs in DG
and RCs by immunohistochemical staining.
Study Design Eighteen cases of DGs and 26 cases of RCs
were analyzed using anti-CD1a marker.
Results CD1a-labeled LCs were observed in 11.1% of
DGs and in 69.2% of RCs, showing a significant correlation
(P < 0.0001; Fisher’s test). In DGs, LCs were only
observed in granulation tissue, showing discrete immunostaining
density. In RCs, LCs exhibited both a round and a
dendritic shape in all epithelial layers. Although a correlation
was observed between immunostaining density and
epithelial thickness, as well as between immunostaining
and inflammatory intensity, the differences were not significant
in radicular cysts.