Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide

Polypeptid mit asparaginase-aktivität, expressionskassette, expressionsvektor, wirtszelle, pharmazeutische zusammensetzung, verfahren zur herstellung eines polypeptids mit asparaginase-aktivität und zur vorbeugung oder behandlung von krebs sowie verwendung eines polypeptids

dc.contributorSouza, Tatiana de Arruda Campos Brasil de
dc.contributorZanchin, Nilson Ivo Tonin
dc.contributorMorais, Stephanie Bath de
dc.date2021-08-31T16:01:59Z
dc.date2021-08-31T16:01:59Z
dc.date2020
dc.date2019-01-18
dc.date.accessioned2023-09-26T21:38:35Z
dc.date.available2023-09-26T21:38:35Z
dc.identifierSOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. EP Pat. 3741850 A1, 25 nov. 2020. 45p.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48862
dc.identifierFundação Oswaldo Cruz
dc.identifierC12N 9/82
dc.identifierC12N 15/55
dc.identifierA61P 35/00
dc.identifierA61K 38/50
dc.identifierC12N 15/66
dc.identifierA61P 35/02
dc.identifierEP19741242.2
dc.identifierBR102018001033-6A2
dc.identifierEP3741850A1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873093
dc.descriptionThe present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer.
dc.descriptionBrasil
dc.descriptionOrganização Mundial para Propriedade Intelectual OMPI
dc.descriptionChina
dc.descriptionEscritório de Patentes Europeu
dc.descriptionEstados Unidos da América
dc.descriptionÍndia
dc.descriptionCanadá
dc.formatapplication/pdf
dc.languageeng
dc.publisherEuropean Patent Office
dc.rightsopen access
dc.subjectAsparaginase
dc.subjectCâncer
dc.subjectAsparaginase
dc.subjectCancer
dc.titlePolypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide
dc.titlePolypeptid mit asparaginase-aktivität, expressionskassette, expressionsvektor, wirtszelle, pharmazeutische zusammensetzung, verfahren zur herstellung eines polypeptids mit asparaginase-aktivität und zur vorbeugung oder behandlung von krebs sowie verwendung eines polypeptids
dc.typePatent


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