Patent
Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide
Polypeptide a activite asparaginase, cassette d'expression, vecteur d'expression, cellule hote, composition pharmaceutique, procedes pour produire un polypeptide a activite aspara ginase et pour prevenir ou traiter le cancer, et utilisation d'un polypeptide
Registro en:
SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. CA Pat. 3105326, 25 jul. 2019. 65p.
Fundação Oswaldo Cruz
A61K 38/50
A61P 35/02
C12N 15/66
A61P 35/00
C12N 15/55
CA3105326A1
BR102018001033-6A2
CA3105326A1
Autor
Souza, Tatiana de Arruda Campos Brasil de
Zanchin, Nilson Ivo Tonin
Morais, Stephanie Bath de
Resumen
The present invention relates to polypeptides with asparaginase activity, which have an increased self-processing rate in comparison to wild-type human L-asparaginase (ASRGL1), said polypeptides having a mutation in the glycine-rich loop of ASRGL1, denominated the HGG (Histidine 8-Glycine 9-Glycine 10) loop. Polynucleotides encoding the polypeptides of the invention, expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the polypeptide of the invention in manufacturing a medication for preventing or treating cancer, and methods for producing the polypeptide of the invention and for preventing or treating cancer are also described herein. Brasil Organização Mundial para Propriedade Intelectual OMPI Estados Unidos da América Escritório de Patentes Europeu Canadá Índia China
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Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide
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Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide
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Souza, Tatiana de Arruda Campos Brasil de; Zanchin, Nilson Ivo Tonin; Faret, Marcele