Cytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemia

dc.creatorAlmeida, Renata dos Santos
dc.creatorRamos, Alessandra Maria de Luna
dc.creatorLuna, Carlos Feitosa
dc.creatorPedrosa, Francisco
dc.creatorDonadi, Eduardo Antônio
dc.creatorLucena-Silva, Norma
dc.date2019-05-23T13:48:52Z
dc.date2019-05-23T13:48:52Z
dc.date2018
dc.date.accessioned2023-09-26T21:37:39Z
dc.date.available2023-09-26T21:37:39Z
dc.identifierALMEIDA, R. dos S. et al. Cytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemia. Cytokine, v. 102, p. 94–101, 1 Feb. 2018.
dc.identifier1096-0023
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33193
dc.identifier10.1016/j.cyto.2017.07.014
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873047
dc.descriptionFACEPE (APQ-0040-4.00 / 13) e CAPES (PROCAD-177382 / 2013grant). Dra. Lucena-Silva é bolsista do CNPq (CNPq 310364 / 2015-9) e Renata S. Almeida da FundaçãoOswaldo Cruz (FIOCRUZ).
dc.descriptionLeukemic cells can induce defective expression of soluble factors and change marrow cytokine profile, leading to aberrant cell signaling, cell fixation and cell proliferation in bone marrow. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder which accounts for 15% of pediatric ALL. To evaluate the contribution of immunological factors on T-ALL survival, we measured Th1, Th2, Th17 cytokines and soluble HLA-G (sHLA-G) levels in bone marrow from 32 Brazilian children at diagnosis (D0), after induction (D19) and after consolidation (D49) of the chemotherapy phase. Data were analyzed using non-parametric tests, and survival rates were evaluated by Kaplan-Meier method (log-rank test). TNF, IL-10 and IL-6 levels were increased at diagnosis compared to D19 and D49. IL-10 levels<4.57pg/mL at diagnosis were associated with increased survival rate, in presence of positive correlation between IL-2 and IL-17 levels. Increased survival rate was also associated with IFN-γ levels<1.17pg/mL at D49, with a positive correlation observed between IL-4 and IL-2 as well IL-4 and IL-17 levels. In contrast, worse survival rate was associated with IL-2, IL-4 and IL-10 levels imbalance. In addition, increased sHLA-G levels at diagnosis were associated with increased leukocyte count, a well-known factor for poor prognosis. In conclusion, cytokines and sHLA-G play an essential role in marrow T-ALL microenvironment during chemotherapy, especially the immunosuppressive cytokine IL-10 which can be used as biomarker of disease outcome, being also a potential target for novel T-ALL treatments.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectT-cell Acute Lymphoblastic Leukemia
dc.subjectBone marrow
dc.subjectIL-10
dc.subjectIFN-γ
dc.subjectPrognosis
dc.subjectAdolescente
dc.subjectBiomarcadores, tumor / metabolismo
dc.subjectMedula Óssea / imunologia
dc.subjectCriança
dc.subjectCriança, pré-escolar
dc.subjectCitocinas / metabolismo
dc.subjectFêmea
dc.subjectAntígenos HLA-G / metabolismo
dc.subjectHumanos
dc.subjectInterferon-gamma / metabolismo
dc.subjectInterleucina-10 / metabolismo
dc.subjectEstimativa de Kaplan-Meier
dc.subjectMasculino
dc.subjectLeucemia Linfoma Linfoblástica Precursora de Células T / quimioterapia
dc.subjectLeucemia Linfática Linfoblástica Precursora de Células T / imunologia
dc.subjectLeucemia-Linfoma Linfoblástico Precursor de Células T / mortalidade
dc.subjectPrognóstico
dc.subjectSolubilidade
dc.subjectTaxa de sobrevivência
dc.subjectMicroambiente Tumoral / imunologia
dc.titleCytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemia
dc.typeArticle


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