Article
Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
Registro en:
OLIVEIRA, Renato Antônio dos Santos et al. Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 6. p. 378–384, 2016.
0074-0276
10.1590/0074-02760150453
Autor
Oliveira, Renato Antônio dos Santos
Silva, Mayara Marques Carneiro da
Silva, Carlos Eduardo Calzavara
Silva, Ana Maria
Cordeiro, Marli Tenório
Moura, Patrícia Muniz Mendes Freire de
Baptista Filho, Paulo Neves
Marques Júnior, Ernesto Torres de Azevedo
Gonzales Gil, Laura Helena Vega
Resumen
Dengue is an acute febrile disease caused by the mosquito-borne dengue virus (DENV) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. Severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. In the present study we measured type I interferon (IFN-I) transcript and circulating levels in primary and secondary DENV infected patients. We observed that dengue fever (DF) and dengue haemorrhagic fever (DHF) patients express IFN-I differently. While DF and DHF patients express interferon-α similarly (52,71 ± 7,40 and 49,05 ± 7,70, respectively), IFN- β were associated with primary DHF patients. On the other hand, secondary DHF patients were not able to secrete large amounts of IFN- β which in turn may have influenced the high-level of viraemia. Our results suggest that, in patients from our cohort, infection by DENV serotype 3 elicits an innate response characterised by higher levels of IFN- β in the DHF patients with primary infection, which could contribute to control infection evidenced by the low-level of viraemia in these patients. The present findings may contribute to shed light in the role of innate immune response in dengue pathogenesis.