Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives

dc.creatorNeves, Juliana Kelle de Andrade Lemoine
dc.creatorSarinho, S.
dc.creatorMelo, C. M. L. de
dc.creatorPereira, V. R. A.
dc.creatorLima, M. C. A. de
dc.creatorPitta, I. R.
dc.creatorAlbuquerque, M. C. P. A.
dc.creatorGaldino, S. L.
dc.date2018-09-13T12:27:26Z
dc.date2018-09-13T12:27:26Z
dc.date2011
dc.date.accessioned2023-09-26T21:14:46Z
dc.date.available2023-09-26T21:14:46Z
dc.identifierJKAL, N. et al. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 17, n. 3, p. 277–286, 2011.
dc.identifier1678-9199
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28721
dc.identifier10.1590/S1678-91992011000300007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871432
dc.descriptionFundação Federal de Pesquisa e Desenvolvimento (FINEP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionSchistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectIn vitro
dc.subjectImidazolidina
dc.subjectSchistosoma mansoni
dc.subjectIn vitro
dc.subjectImidazolidines
dc.subjectSchistosoma mansoni / imunologia
dc.subjectSchistosoma mansoni / epidemiologia
dc.subjectBrasil / epidemiologia
dc.subjectHumanos
dc.subjectSchistosoma mansoni / efeitos dos fármacos
dc.subjectCitotoxicidade Imunológica
dc.subjectTestes Imunológicos de Citotoxicidade
dc.subjectTécnicas In Vitro
dc.titleImmunological studies and in vitro schistosomicide action of new imidazolidine derivatives
dc.typeArticle


Este ítem pertenece a la siguiente institución