Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations

dc.creatorSucupira, Michel V. F.
dc.creatorMello, Francisco C. A.
dc.creatorSantos, Eneida A.
dc.creatorNiel, Christian
dc.creatorRolla, Valeria C.
dc.creatorArabe, Juçara
dc.creatorGomes, Selma A.
dc.date2019-10-26T18:28:51Z
dc.date2019-10-26T18:28:51Z
dc.date2006
dc.date.accessioned2023-09-26T21:13:22Z
dc.date.available2023-09-26T21:13:22Z
dc.identifierSUCUPIRA, Michel V. F. et al. Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 6, p. 655-660, Sept. 2006.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36723
dc.identifier10.1590/S0074-02762006000600013
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871068
dc.descriptionHepatitis B virus (HBV) molecular profiles were determined for 44 patients who were infected with human immunodeficiency virus (HIV) type 1 and had antibodies to the hepatitis B core antigen (anti-HBc), with and without other HBV serological markers. In this population, 70% of the patients were under lamivudine treatment as a component of antiretroviral therapy. HBV DNA was detected in 14 (32%) patients. Eight out of 12 (67%) HBsAg positive samples, 3/10 (30%) anti-HBc only samples, and 3/22 (14%) anti-HBs positive samples were HBV DNA positive. HBV DNA loads, measured by real time polymerase chain reaction, were much higher in the HBsAg positive patients (mean, 2.5 × 109 copies/ml) than in the negative ones (HBV occult infection; mean, 2.7 × 105 copies/ml). Nine out of the 14 HBV DNA positive patients were under lamivudine treatment. Lamivudine resistant mutations in the polymerase gene were detected in only three patients, all of them belonging to the subgroup of five HBsAg positive, HBV DNA positive patients. A low mean HBV load (2.7 × 105 copies/ml) and an absence of lamivudine resistant mutations were observed among the cases of HBV occult infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectVírus da Hepatite B
dc.subjectMutações
dc.subjectResistência a medicamentos
dc.subjectVírus da imunodeficiência humana
dc.subjectLamivudina
dc.subjectHepatitis B virus
dc.subjectHuman immunodeficiency virus
dc.subjectLamivudine
dc.subjectDrug resistance
dc.subjectMutations
dc.titlePatterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations
dc.typeArticle


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