Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review

dc.creatorGomes, Paulo André Teixeira de Moraes
dc.creatorPena, Lindomar J.
dc.creatorLeite, Ana C. Lima
dc.date2019-10-17T13:23:55Z
dc.date2019-10-17T13:23:55Z
dc.date2019
dc.date.accessioned2023-09-26T21:12:33Z
dc.date.available2023-09-26T21:12:33Z
dc.identifierGOMES, Paulo André Teixeira de Moraes; PENA, Lindomar J.; LEITE, Ana C. Lima. Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review. Mini Reviews in Medicinal Chemistry, v. 19, n. 1, p. 56–62, 2019.
dc.identifier1389-5575
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36515
dc.identifier10.2174/1389557518666180424093305
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870856
dc.descriptionArboviruses have been spreading rapidly throughout the Western Hemisphere in recent decades. Among the arboviruses with high morbidity and mortality are the members of the Alphavirus and Flavivirus genera. Within the first genus, Chikungunya Virus (CHIKV) is considered one of the most challenging human arboviral infection worldwide, against which there is no specific antivirals. Flaviviruses are some of the main viruses responsible for encephalitis, haemorrhagic disease and developmental defects. Dengue virus (DENV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV) and Zika Virus (ZIKV) are examples of flaviviruses without clinically approved antiviral agents. Thus, the search for new antivirals becomes highly important. One of the strategies that can be employed to obtain new drugs is the identification and utilization of privileged structures. Isatin is an example of a privileged molecular framework, displaying a broad spectrum of biological activities, including antiviral action. Obtaining and studying the antiviral properties of isatin derivatives have helped to identify important agents with potential activity against different arboviruses. This article reviews some of these isatin derivatives, their structures and antiviral properties reported against this important group of viruses.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectArbovirus
dc.subjectChikungunya virus
dc.subjectDengue virus
dc.subjectIsatin
dc.subjectJapanese encephalitis virus
dc.subjectWest Nile virus
dc.subjectZika virus
dc.subjectAnimais
dc.subjectAntivirais / química
dc.subjectAntivirais / farmacologia
dc.subjectAntivirais / uso terapêutico
dc.subjectInfecções por Arbovirus / tratamento farmacológico
dc.subjectArbovirus / efeitos dos fármacos
dc.subjectDescoberta de Drogas / métodos
dc.subjectHumanos
dc.subjectIsatina / chemistry
dc.subjectIsatina / farmacologia
dc.subjectIsatina / uso terapêutico
dc.titleIsatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review
dc.typeArticle


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