Flavonoids as molecules with anti-Zika virus activity

dc.creatorCataneo, Allan Henrique Depieri
dc.creatorÁvila, Eloah Pereira
dc.creatorMendes, Larissa Albuquerque de Oliveira
dc.creatorOliveira, Viviane Guedes de
dc.creatorFerraz, Camila Rodrigues
dc.creatorAlmeida, Mauro Vieira de
dc.creatorFrabasile, Sandra
dc.creatorSantos, Claudia Nunes Duarte dos
dc.creatorVerri Júnior, Waldiceu Aparecido
dc.creatorBordignon, Juliano
dc.creatorWowk, Pryscilla Fanini
dc.date2021-11-09T15:33:28Z
dc.date2021-11-09T15:33:28Z
dc.date2021
dc.date.accessioned2023-09-26T21:10:37Z
dc.date.available2023-09-26T21:10:37Z
dc.identifierCATANEO, Allan Henrique Depieri et al. Flavonoids as molecules with anti-Zika virus activity. Frontiers in Microbiology, v. 12, n. 710359, p. 1-16, 2021.
dc.identifier1664-302X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49743
dc.identifier10.3389/fmicb.2021.710359
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870369
dc.descriptionZika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015). Most ZIKV-infected individuals are asymptomatic or present with a self-limiting disease and nonspecific symptoms such as fever, myalgia, and headache. However, in French Polynesia and Brazil, ZIKV outbreaks led to the diagnosis of congenital malformations and microcephaly in newborns and Guillain-Barré syndrome (GBS) in adults. These new clinical presentations raised concern from public health authorities and highlighted the need for anti-Zika treatments and vaccines to control the neurological damage caused by the virus. Despite many efforts in the search for an effective treatment, neither vaccines nor antiviral drugs have become available to control ZIKV infection and/or replication. Flavonoids, a class of natural compounds that are well-known for possessing several biological properties, have shown activity against different viruses. Additionally, the use of flavonoids in some countries as food supplements indicates that these molecules are nontoxic to humans. Thus, here, we summarize knowledge on the use of flavonoids as a source of anti-ZIKV molecules and discuss the gaps and challenges in this area before these compounds can be considered for further preclinical and clinical trials.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectAntiviral Agents
dc.subjectFlavonoids
dc.subjectBiological Products
dc.subjectVirus Zika
dc.subjectTherapeutics
dc.subjectAntivirales
dc.subjectFlavonoides
dc.subjectProductos Biológicos
dc.subjectTerapéutica
dc.subjectAntiviraux
dc.subjectFlavonoïdes
dc.subjectProduits biologiques
dc.subjectThérapeutique
dc.subjectAntivirais
dc.subjectFlavonoides
dc.subjectProdutos Biológicos
dc.subjectZika virus
dc.subjectTerapêutica
dc.titleFlavonoids as molecules with anti-Zika virus activity
dc.typeArticle


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