Article
Hairless mice as an experimental model of infection with Leishmania amazonensis
Registro en:
ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania amazonensis. Experimental Parasitology, v. 157, p. 138-144, 2015.
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Autor
Araujo, Vanessa Carneiro Pereira
Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
Resumen
HRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis
induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 106 promastigotes
into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c
mice were infected and used as control. Hairless mice were susceptible to L. (L.) amazonensis infection
and a progressive increase in number of parasites and footpad thickness was detected over time. Signals
of dissemination and visceralization were confirmed by the presence of parasite in the draining lymph
node of lesion and spleen, at different times post infection. IL-10 gene expression evaluated by RT-PCR
was significantly higher in Hairless mice at 60 days post infection, corroborating the pattern of susceptibility.
These results point this inbred strain as a promising susceptible model for the study of
experimental infection induced by L. (L.) amazonensis. This model would allow the use of other infection