Article
A Stroll Through the History of Monoxenous Trypanosomatids Infection in Vertebrate Hosts
Registro en:
BOUCINHA, Carolina et al. A Stroll Through the History of Monoxenous Trypanosomatids Infection in Vertebrate Hosts. Frontiers in Cellular and Infection Microbiology, v. 12, Article 804707, p. 1 - 7, Feb. 2022.
2235-2988
10.3389/fcimb.2022.804707
Autor
Boucinha, Carolina
Andrade Neto, Valter Viana
Ennes-Vidal, Vitor
Branquinha, Maria Helena
Santos, André Luis Souza dos
Santos, Eduardo Caio
d’Avila-Levy, Claudia Masini
Resumen
The Trypanosomatidae family encompasses unicellular flagellates and obligate parasites
of invertebrates, vertebrates, and plants. Trypanosomatids are traditionally divided into
heteroxenous, characterized by the alternation of the life cycle between an insect vector
and a plant or a vertebrate host, including humans being responsible for severe diseases;
and monoxenous, which are presumably unique parasites of invertebrate hosts.
Interestingly, studies reporting the occurrence of these monoxenous trypanosomatids
in humans have been gradually increasing, either associated with Leishmania co-infection,
or supposedly alone either in immunocompromised or even more sporadically in
immunocompetent hosts. This review summarizes the first reports that raised the
hypothesis that monoxenous trypanosomatids could be found in vertebrate hosts till
the most current reports on the occurrence of Crithidia spp. alone in immunocompetent
human patients.