Article
VP7 Gene of Human Rotavirus A Genotype G5: Phylogenetic Analysis Reveals the Existence of Three Different Lineages Worldwide
Registro en:
SILVA, Marcelle Figueira Marques da; et al. VP7 Gene of Human Rotavirus A Genotype G5: Phylogenetic Analysis Reveals the Existence of Three Different Lineages Worldwide. Journal of Medical Virology, v.83, p.357–366, 2011.
0146-6615
1096-9071
Autor
Silva, Marcelle Figueira Marques da
Tort, Luis Fernando López
Gómez, Mariela Martínez
Assis, Rosane Maria Santos
Volotão, Eduardo de Mello
Mendonça, Marcos César Lima de
Bello, Gonzalo
Leite, José Paulo Gagliardi
Resumen
Group A rotavirus (RV-A) genotype G5, which is
common in pigs, was also detected in children
with severe diarrhea in Brazil, Argentina, Paraguay,
Cameroon, China, Thailand, and Vietnam.
To evaluate the evolutionary relationship among
RV-A G5 strains, the VP7 and VP4 genes of 28
Brazilian RV-A G5 human strains, sampled
between 1986 and 2005, were sequenced and
compared with other RV-A G5 strains currently
circulating worldwide in animals and humans.
The phylogenetic analysis of RV-A G5 VP7 gene
strains demonstrates the existence of three
main lineages: (a) Lineage I: Brazilian strains
grouped with three porcine strains from Thailand;
(b) Lineage II: porcine, bovine, and equine
strains from different regions; (c) Lineage III:
human strains isolated in Asia and Africa, and
two porcine strains from Argentina. The VP8*
(*non-typable) subunit of VP4 gene sequencing
showed that all P[8] strains fell into three major
genetic lineages: P[8]-1; P[8]-2; and P[8]-3. These
results showed that the RV-A G5 strains circulating
in humans are the result of two independent
zoonotic transmission events, most likely from
pigs. 2030-01-01