Article
Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants
Registro en:
MONTEIRO, Jacqueline Pontes; et al. Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants. Revista da Sociedade Brasileira de Medicina Tropical, v.47, n.6, p.692-700, Nov-Dec, 2014.
1678-9849
10.1590/0037-8682-0226-2014
Autor
Monteiro, Jacqueline Pontes
Santa Cruz, Maria Letícia
Pinhata, Marisa Márcia Mussi
Salomão, Roberta Garcia
Jordão Junior, Alceu
Hance, Laura Freimanis
Read, Jennifer Suzanne
Pilotto, José Henrique da Silva
Cohen, Rachel Ann
Stoszek, Sonia Karolina
Siberry, George Kelly
Resumen
Introduction: We hypothesized that nutritional defi ciency would be common in a cohort of postpartum, human immunodefi ciency
virus (HIV)-infected women and their infants. Methods: Weight and height, as well as blood concentrations of retinol,
α-tocopherol, ferritin, hemoglobin, and zinc, were measured in mothers after delivery and in their infants at birth and at 6-12
weeks and six months of age. Retinol and α-tocopherol levels were quantifi ed by high performance liquid chromatography,
and zinc levels were measured by atomic absorption spectrophotometry. The maternal body mass index during pregnancy was
adjusted for gestational age (adjBMI). Results: Among the 97 women 19.6% were underweight. Laboratory abnormalities were
most frequently observed for the hemoglobin (46.4%), zinc (41.1%), retinol (12.5%) and ferritin (6.5%) levels. Five percent
of the women had mean corpuscular hemoglobin concentrations < 31g/dL. The most common defi ciency in the infants was
α-tocopherol (81%) at birth; however, only 18.5% of infants had defi cient levels at six months of age. Large percentages of
infants had zinc (36.8%) and retinol (29.5%) defi ciencies at birth; however, these percentages decreased to 17.5% and 18.5%,
respectively, by six months of age. No associations between infant micronutrient defi ciencies and either the maternal adjBMI
category or maternal micronutrient defi ciencies were found. Conclusions: Micronutrient defi ciencies were common in HIVinfected
women and their infants. Micronutrient defi ciencies were less prevalent in the infants at six months of age. Neither
underweight women nor their infants at birth were at increased risk for micronutrient defi ciencies.