Force patterns of hypoxic myocardium applied to oxygenated muscle preparations: Comparison with effects of regional ischemia on the contraction of non-ischemic myocardium

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorShimizu, Gen
dc.creatorWiegner, Allen W.
dc.creatorGaasch, William H.
dc.creatorConrad, Chester H.
dc.creatorCicogna, Antonio C.
dc.creatorBing, Oscar H.L.
dc.date2014-05-27T11:18:08Z
dc.date2016-10-25T18:14:04Z
dc.date2014-05-27T11:18:08Z
dc.date2016-10-25T18:14:04Z
dc.date1996-12-01
dc.date.accessioned2017-04-06T00:48:07Z
dc.date.available2017-04-06T00:48:07Z
dc.identifierCardiovascular Research, v. 32, n. 6, p. 1038-1046, 1996.
dc.identifier0008-6363
dc.identifierhttp://hdl.handle.net/11449/64896
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64896
dc.identifier10.1016/S0008-6363(96)00162-9
dc.identifier2-s2.0-0030300051
dc.identifierhttp://dx.doi.org/10.1016/S0008-6363(96)00162-9
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886671
dc.descriptionObjective: To examine the basis for local wall motion abnormalities commonly seen in patients with ischemic heart disease, computer-controlled isolated muscle studies were carried out. Methods: Force patterns of physiologically sequenced contractions (PSCs) from rat left ventricular muscle preparations under well-oxygenated conditions and during periods of hypoxia and reoxygenation were recorded and stored in a computer. Force patterns of hypoxic-reoxygenating and oxygenated myocardium were applied to oxygenated and hypoxic-reoxygenating myocardium, respectively. Results: Observed patterns of shortening and lengthening closely resemble those obtained from ischemic and non-ischemic myocardial segments using ultrasonic crystals in intact dog hearts during coronary occlusion and reperfusion, and are similar to findings reported in angiographic studies of humans with coronary artery disease. Conclusion: The current study, demonstrating motions of oxygenated isolated muscle preparations which are similar to those in perfused segments of intact hearts with regional ischemia, supports the concept that the multiple motions of both ischemic and non-ischemic segments seen in regional myocardial disease can be explained by interactions of strongly and weakly contracting muscle during the physiologic cardiac cycle.
dc.languageeng
dc.relationCardiovascular Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcontractile function
dc.subjectmyocardial hypoxia
dc.subjectmyocardial ischemia
dc.subjectrat, ventricle
dc.subjectreoxygenation
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcoronary artery disease
dc.subjectheart muscle ischemia
dc.subjecthypoxia
dc.subjectmuscle contraction
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectanimal
dc.subjectcomparative study
dc.subjectheart contraction
dc.subjectheart muscle reperfusion
dc.subjectheart papillary muscle
dc.subjectin vitro study
dc.subjectmale
dc.subjectminicomputer
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrat strain
dc.subjectAnimals
dc.subjectMale
dc.subjectMinicomputers
dc.subjectMyocardial Contraction
dc.subjectMyocardial Ischemia
dc.subjectMyocardial Reperfusion
dc.subjectPapillary Muscles
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.titleForce patterns of hypoxic myocardium applied to oxygenated muscle preparations: Comparison with effects of regional ischemia on the contraction of non-ischemic myocardium
dc.typeOtro


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