Article
SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface
Registro en:
GRANJA, Marcelo Gomes et al. SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface. Neuroimmunomodulation, v. 28, 32p, Apr. 2021
1021-7401
10.1159/000515556
Autor
Granja, Marcelo Gomes
Oliveira, Amanda Candida da Rocha
Figueiredo, Camila Saggioro de
Gomes, Alex Portes
Ferreira, Erica Camila
Araujo, Elizabeth Giestal de
Faria Neto, Hugo Caire de Castro
Resumen
Coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome-related coronavirus 2 (SARS CoV-2) has devastating effects on the population worldwide.
Given this scenario, the extent of the impact of the disease
on more vulnerable individuals, such as pregnant women, is
of great concern. Although pregnancy may be a risk factor in
respiratory virus infections, there are no considerable differ ences regarding COVID-19 severity observed between preg nant and nonpregnant women. In these circumstances, an
emergent concern is the possibility of neurodevelopmental
and neuropsychiatric harm for the offspring of infected
mothers. Currently, there is no stronger evidence indicating
vertical transmission of SARS-CoV-2; however, the exacer bated inflammatory response observed in the disease could
lead to several impairments in the offspring’s brain. Further more, in the face of historical knowledge on possible long term consequences for the progeny’s brain after infection by
viruses, we must consider that this might be another delete rious facet of COVID-19. In light of neuroimmune interac tions at the maternal-fetal interface, we review here the pos sible harmful outcomes to the offspring brains of mothers
infected by SARS-CoV-2.