Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission

dc.creatorRoundy, Christopher Michael
dc.creatorAzar, Sasha R
dc.creatorRossi, Shannan L
dc.creatorHuang, Jing H
dc.creatorLeal, Grace
dc.creatorYun, Ruimei
dc.creatorFernandez-Salas, Ildefonso
dc.creatorVitek, Christopher J
dc.creatorPaploski, Igor Adolfo Dexheimer
dc.creatorKitron, Uriel
dc.creatorRibeiro, Guilherme de Sousa
dc.creatorHanley, Kathryn A
dc.creatorWeaver, Scott C
dc.creatorVasilakis, Nikos
dc.date2018-04-02T18:23:18Z
dc.date2018-04-02T18:23:18Z
dc.date2017
dc.date.accessioned2023-09-26T20:54:55Z
dc.date.available2023-09-26T20:54:55Z
dc.identifierROUNDY, C. M. et al. Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission. Emerging Infectious Diseases, v. 23, n. 4, p. 625-632, 2017.
dc.identifier1080-6040
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25562
dc.identifier10.3201/eid2304.161484
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866086
dc.descriptionInstitute for Human Infections and Immunity, grants R24AI120942 and 1U01AI115577 from the National Institutes of Health, as well as by National Institutes of Health grant 1R15AI113628-01 (to K.A.H.), Brazilian national Council of Technological and Scientific Development grants 440891/2016-7 and 370 400830/2013-2 (GSR), and Brazilian Coordination for the Improvement of Higher Education grant 440891/2016-7 (GSR).
dc.descriptionTo test whether Zika virus has adapted for more efficient transmission by Aedes aegypti mosquitoes, leading to recent urban outbreaks, we fed mosquitoes from Brazil, the Dominican Republic, and the United States artificial blood meals containing 1 of 3 Zika virus strains (Senegal, Cambodia, Mexico) and monitored infection, dissemination, and virus in saliva. Contrary to our hypothesis, Cambodia and Mexica strains were less infectious than the Senegal strain. Only mosquitoes from the Dominican Republic transmitted the Cambodia and Mexica strains. However, blood meals from viremic mice were more infectious than artificial blood meals of comparable doses; the Cambodia strain was not transmitted by mosquitoes from Brazil after artificial blood meals, whereas 61% transmission occurred after a murine blood meal (saliva titers up to 4 log10infectious units/collection). Although regional origins of vector populations and virus strain influence transmission efficiency, Ae. aegypti mosquitoes appear to be competent vectors of Zika virus in several regions of the Americas.
dc.formatapplication/pdf
dc.languageeng
dc.publisherCenters for Disease Control and Prevention
dc.rightsopen access
dc.subjectAedes aegypti
dc.subjectZika
dc.subjectZika virus
dc.subjectArbovirus
dc.subjectFlavivirus
dc.subjectMosquitos transmissão
dc.subjectCompetência vetorial
dc.subjectInfecções transmitidas por vetores
dc.subjectVírus
dc.subjectAedes aegypti
dc.subjectZika
dc.subjectZika virus
dc.subjectArbovirus
dc.subjectFlaviviruses
dc.subjectMosquitoes transmission
dc.subjectVector competence
dc.subjectVector-borne infections
dc.subjectViruses
dc.titleVariation in Aedes aegypti Mosquito Competence for Zika Virus Transmission
dc.typeArticle


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