Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.

dc.creatorRocha, Cláudia Quintino da
dc.creatorQueiroz, Emerson Ferreira
dc.creatorMeira, Cássio Santana
dc.creatorMoreira, Diogo Rodrigo Magalhães
dc.creatorSoares, Milena Botelho Pereira
dc.creatorMarcourt, Laurence
dc.creatorVilegas, Wagner
dc.creatorWolfender, Jean-Luc
dc.date2014-09-26T17:59:03Z
dc.date2014-09-26T17:59:03Z
dc.date2014
dc.date.accessioned2023-09-26T20:50:18Z
dc.date.available2023-09-26T20:50:18Z
dc.identifierROCHA, C. et al. Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. Journal of Natural Products, v. 77, n. 66, p. 1345-1350, 2014.
dc.identifier1520-6025
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8460
dc.identifier10.1021/np401060j
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864771
dc.descriptionThe nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. Targeted isolation of the active constituents led to the isolation of three new dimeric flavonoids (1-3), and their structures were elucidated using UV, NMR, and HRMS analysis, as well as by chemical derivatization. The anti-T. cruzi activity and cytotoxicity toward mammalian cells were determined for these substances. Compound 1 exhibited no activity toward T. cruzi, while flavonoids 2 and 3 exhibited selective activity against these trypomastigotes. Compounds 2 and 3 inhibited the parasite invasion process and its intracellular development in host cells with similar potencies to benznidazole. In addition, compound 2 reduced the blood parasitemia of T. cruzi-infected mice. This study has revealed that these two dimeric flavonoids represent potential anti-T. cruzi lead compounds for further drug development.
dc.formatapplication/pdf
dc.languageeng
dc.publisherACS Publications
dc.rightsopen access
dc.subjectBignoniaceae/química
dc.subjectFlavonoides/isolamento & purificação
dc.subjectFlavonoides/farmacologia
dc.subjectTripanossomicidas/isolamento & purificação
dc.subjectTripanossomicidas/farmacologia
dc.subjectTrypanosoma cruzi/efeitos de drogas
dc.subjectBrasil
dc.subjectCercopithecus aethiops
dc.subjectFlavonoides/sangue
dc.subjectFlavonoides/química
dc.subjectMacrófagos Peritoneais/efeitos de drogas
dc.subjectCamundongos
dc.subjectEstrutura Molecular
dc.subjectTestes de Sensibilidade Parasitária
dc.subjectTripanossomicidas/sangue
dc.subjectTripanossomicidas/química
dc.subjectCelulas vero
dc.titleDimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.
dc.typeArticle


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