Müller cells and diabetic retinopathy.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSchellini, Silvana Artioli
dc.creatorGregório, E. A.
dc.creatorSpadella, César Tadeu
dc.creatorMachado, J. L.
dc.creatorde-Moraes-Silva, M. A.
dc.date2014-05-27T11:18:01Z
dc.date2016-10-25T18:13:35Z
dc.date2014-05-27T11:18:01Z
dc.date2016-10-25T18:13:35Z
dc.date1995-09-01
dc.date.accessioned2017-04-06T00:46:19Z
dc.date.available2017-04-06T00:46:19Z
dc.identifierBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 28, n. 9, p. 977-980, 1995.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/64637
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64637
dc.identifier2-s2.0-0029366843
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886445
dc.descriptionMüller cells provide nutrition for neural cells. We studied the structure and ultrastructure of Müller cells in the retina of thirty 3-month old Wistar rats, divided equally into 3 groups: normal rats, alloxan diabetic rats and treated alloxan diabetic rats, 1 and 12 months after induction of diabetes. We observed that the Müller cell nuclei under light microscope examination had hexagonal shape and higher density than the other nuclei. Differences between groups could be observed only by electron microscopy. In the diabetic rats, Müller cells presented dispersion of nuclear chromatin and electrondense nuclear granulations, with the presence of increased glycogen, dense bodies and lysosomes in the cytoplasm. The alterations were more frequent in the perivascular region and at 12 months. The treated diabetic rats exhibited some alterations we observed in diabetic rats, but these alterations were less intense. We conclude that, despite the treatment, the diabetic retinopathy continues to evolve.
dc.languageeng
dc.relationBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanimal
dc.subjectdiabetic retinopathy
dc.subjectexperimental diabetes mellitus
dc.subjectglia
dc.subjectpathology
dc.subjectrat
dc.subjectretina
dc.subjectultrastructure
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Retinopathy
dc.subjectNeuroglia
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRetina
dc.titleMüller cells and diabetic retinopathy.
dc.typeOtro


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