Article
Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil
Registro en:
SOUSA JR, Ivanildo et al. Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil. Viruses, v. 13, 1370, p. 1-32, July 2021.
1999-4915
10.3390/v13071370
Autor
Sousa Jr., Ivanildo P.
Santos, Flavia B. dos
Paula, Vanessa S. de
Vieira, Tuane C. R. G.
Dias, Helver G.
Barros, Caroline A.
Silva, Edson E. da
Resumen
Virus-induced infections of the central nervous system (CNS) are among the most serious
problems in public health and can be associated with high rates of morbidity and mortality, mainly in
low- and middle-income countries, where these manifestations have been neglected. Typically, herpes
simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in
immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most
common in immunocompromised individuals. Arboviruses have also been associated with outbreaks
with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a
current lack of understanding in Brazil about the most common viruses involved in CNS infections.
In this review, we briefly summarize the most recent studies and findings associated with the CNS, in
addition to epidemiological data that provide extensive information on the circulation and diversity
of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the
prion-associated diseases. This review provides readers with better knowledge of virus-associated
CNS infections. A deeper understanding of these infections will support the improvement of the
current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of
neurotropic viruses.