Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor

dc.creatorDonato, Mariana Aragão Matos
dc.creatorSaraiva, Karina Lidianne Alcântara
dc.creatorSoares e Silva, Amanda Karolina
dc.creatorWanderley, Maria Inês
dc.creatorPeixoto, Christina Alves
dc.date2018-07-09T19:38:21Z
dc.date2018-07-09T19:38:21Z
dc.date2009
dc.date.accessioned2023-09-26T20:43:29Z
dc.date.available2023-09-26T20:43:29Z
dc.identifierDONATO, M. A. M. et al. Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor. Micron, v. 40, n. 8, p. 845–850, dez. 2009.
dc.identifier1878-4291
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27377
dc.identifier10.1016/j.micron.2009.06.007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862711
dc.descriptionEste trabalho foi apoiado pelas agências de fomento brasileiras Fundação Oswaldo Cruz (FIOCRUZ) e pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
dc.descriptionVardenafil citrate is a potent vasodilator used in the treatment of patients with erectile dysfunction. Its mechanism of action is based on the selective inhibition of phosphodiesterase-5 (PDE5), specific to guanosine 3',5'-cyclic monophosphate (cGMP). Recently, chronic treatment with Vardenafil has been successfully used in cases of pulmonary hypertension and, despite being used in high doses for long periods, little is known about its effects on other systems. In the present study, female mice were treated daily with 5 mg/kg Vardenafil for 4 weeks, after which the ovaries were collected for morphological analyses and sera were collected for biochemical assays. This study found that treatment with Vardenafil decreased HDL serum levels and the number of antral follicles as well as induced lesser lipid content in luteal cells, suggesting that high levels of cGMP may affect follicle development.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectiPDE5
dc.subjectFolículo
dc.subjectCorpo lúteo
dc.subjectUltraestrutura
dc.subjectHDL
dc.subjectiPDE5
dc.subjectFollicle
dc.subjectCorpus luteum
dc.subjectUltrastructure
dc.subjectHDL
dc.subjectAnimais
dc.subjectInibidores enzimáticos / administração & dosagem
dc.subjectInibidores enzimáticos / farmacologia
dc.subjectFêmea
dc.subjectHistocitoquímica
dc.subjectImidazoles / administração & dosagem
dc.subjectImidazoles / farmacologia
dc.subjectLipoproteínas, HDL / análise
dc.subjectCélulas Luteais / efeitos de drogas
dc.subjectCélulas Luteais / ultraestrutura
dc.subjectRatos
dc.subjectMicroscopia Eletrônica, Transmissão
dc.subjectFolículo Ovariano / efeitos de drogas
dc.subjectFolículo Ovariano / crescimento & desenvolvimento
dc.subjectInibidores da Fosfodiesterase 5
dc.subjectPiperazinas / administração & dosagem
dc.subjectPiperazinas / farmacologia
dc.subjectSoro / química
dc.subjectSulfonas / administração & dosagem
dc.subjectSulfonas / farmacologia
dc.subjectTriazinas / administração & dosagem
dc.subjectTriazinas / farmacologia
dc.subjectDihydrochloride Vardenafil
dc.titleFollicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor
dc.typeArticle


Este ítem pertenece a la siguiente institución