Pathology of periportal fibrosis involution in human schistosomiasis.

dc.creatorAndrade, Zilton de Araújo
dc.creatorPeixoto, Ediriomar
dc.date2012-10-22T18:36:05Z
dc.date2012-10-22T18:36:05Z
dc.date1992
dc.date.accessioned2023-09-26T20:40:16Z
dc.date.available2023-09-26T20:40:16Z
dc.identifierANDRADE, Z.A.; PEIXOTO, E. Pathology of periportal fibrosis involution in human schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 34, n. 4, p. 263-72, jul.-aug. 1992.
dc.identifier0036-4665
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5707
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861697
dc.descriptionOptical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectMatrix degradation
dc.subjectFibrosis
dc.subjectSchistosomiasis
dc.subjectCollagen
dc.subjectChemotherapy
dc.subjectFígado/patologia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectBiópsia
dc.subjectColágeno/metabolismo
dc.subjectFeminino
dc.subjectFibrose
dc.subjectHepatomegalia/etiologia
dc.subjectHepatomegalia/metabolismo
dc.subjectHepatomegalia/patologia
dc.subjectHumanos
dc.subjectImunoistoquímica
dc.subjectFígado/metabolismo
dc.subjectMasculino
dc.subjectMicroscopia Eletrônica
dc.subjectMeia-Idade
dc.subjectEsquistossomose mansoni/complicações
dc.subjectEsquistossomose mansoni/metabolismo
dc.subjectEsplenomegalia/etiologia
dc.subjectEsplenomegalia/metabolismo
dc.subjectEsplenomegalia/patologia
dc.titlePathology of periportal fibrosis involution in human schistosomiasis.
dc.typeArticle


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