Article
Detection of Oseltamivir-Resistant Pandemic Influenza A(H1N1)pdm2009 in Brazil: Can Community Transmission Be Ruled Out?
Registro en:
SOUZA, Thiago Moreno L.; et al. Detection of Oseltamivir-Resistant Pandemic Influenza A(H1N1)pdm2009 in Brazil: Can Community Transmission Be Ruled Out?. PLoS One, v.8, n.11, e80081, 6p, Nov. 2013.
10.1371/journal.pone.0080081
Autor
Souza, Thiago Moreno L
Resende, Paola C.
Rodrigues, Natalia Fintelman
Gregianini, Tatiana Schaffer
Ikuta, Nilo
Fernandes, Sandra Bianchini
Cury, Ana Luisa Furtado
Rosa, Maria do Carmo Debur
Siqueira, Marilda Agudo Mendonça Teixeira de
Resumen
Although surveillance efforts that monitor the emergence of drug-resistant strains of influenza are critical, systematic
analysis is overlooked in most developing countries. We report on the occurrence of strains of pandemic influenza
A(H1N1)pdm09 with resistance and decreased susceptibility to oseltamivir (OST) in Brazil in 2009, 2011 and 2012.
We found 7 mutant viruses, 2 with the mutation S247N and other 5 with the mutation H275Y. Most of these viruses
were from samples concentrated in the southern region of Brazil. Some of these resistant viruses were detected prior
to the initiation of OST treatment, suggesting that community transmission of mutant viruses may exist. Moreover, we
show that one of these OST-resistant (H275Y) strains of A(H1N1)pdm09 was discovered in the tri-border region
between Brazil, Argentina and Paraguay, highlighting that this strain could also be found in other Latin American
countries. Our findings reinforce the importance of enhanced antiviral resistance surveillance in Brazil and in other
Latin American countries to confirm or rule out the community transmission of OST-resistant strains of
A(H1N1)pdm09.