Article
Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy
Registro en:
COELHO Paulo Marcos Zech et al. Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy. Acta Trop., 108, n. 2-3, p. 104-8, 2008. doi: 10.1016/j.actatropica.2008.01.010.v.
0001-706X
10.1016/j.actatropica.2008.01.010
Autor
Coelho, Paulo Marcos Zech
Andrade, Zilton de Araújo
Mello, Rômulo Teixeira de
Costa, Guilherme
Dias, Flávia Sílvia Guimarães
Cunha-Melo, José Renan
Resumen
Hepatic histopathological changes due to Schistosoma mansoni infection in the mouse presented considerable improvement following partial hepatectomy, both during early (acute) and late (chronic) infections, and especially when surgery was preceded by curative chemotherapy. A 60% hepatectomy removed a great deal of a diseased liver that was replaced by a normal-looking tissue in which schistosomal lesions appeared fewer and scattered. After chemotherapy, residual fibrosis left either from cured acute and chronic schistosomal lesions, almost completely disappeared when the regenerated liver was examined a month afterwards. These marked changes, brought about by hepatectomy in experimental hepatic schistosomiasis, illustrate the fact that post-hepatectomy regeneration tends to restore the normal structure of the liver, even in a diseased organ. 2099-12-31