Article
Transmission of Chikungunya Virus in an Urban Slum, Brazil
Registro en:
ANJOS, Rosângela O. et al. Transmission of Chikungunya Virus in an Urban Slum, Brazil. Emerging Infectious Disease, v. 26, n. 7, p. 1364-1373, 2020.
1080-6040
10.3201/eid2607.190846
Autor
Anjos, Rosângela O
Mugabe, Vánio André
Moreira, Patrícia S S
Carvalho, Caroline X
Portilho, Moyra M
Cunha, Antonio Ricardo Khouri
Sacramento, Gielson A
Nery Junior, Nivison Ruy Rocha
Reis, Mitermayer Galvão dos
Kitron, Uriel D
Ko, Albert Icksang
Costa, Federico
Ribeiro, Guilherme de Sousa
Resumen
Brazilian National
Council for Scientific and Technological Development (grants 400830/2013-2, 440891/2016-7, and 421522/2016-0 to G.S.R., grant 439967/2016-3 to R.K., and scholarships
to M.G.R., U.K., and G.S.R.); the Coordination for the
Improvement of Higher Education Personnel, Brazilian Ministry of Education (grant 88887.130746/2016-00 to G.S.R.); the Research Support Foundation for the State of Bahía (grant FAPESB PET0022/2016 to G.S.R.); the US National Institutes of Health (grants NIAID 5 R01 AI121207, FIC 5 R01 TW009504, FIC 5 R25 TW009338, and NIAID 5 U01 AI088752 to A.I.K.); the Wellcome Trust (102330/Z/13/Z to F.C.); the Yale School of Public Health; the Oswaldo Cruz Foundation; the Federal University of Bahia; and the Department of Science and Technology, Secretariat of Science, Technology and Strategic Inputs, Brazilian Ministry of Health. After a chikungunya outbreak in Salvador, Brazil, we performed a cross-sectional, community-based study of 1,776 inhabitants to determine chikungunya virus (CHIKV) seroprevalence, identify factors associated with exposure, and estimate the symptomatic infection rate. From November 2016 through February 2017, we collected sociodemographic and clinical data by interview and tested serum samples for CHIKV IgG. CHIKV seroprevalence was 11.8% (95% CI 9.8%-13.7%), and 15.3% of seropositive persons reported an episode of fever and arthralgia. Infections were independently and positively associated with residences served by unpaved streets, a presumptive clinical diagnosis of chikungunya, and recall of an episode of fever with arthralgia in 2015-2016. Our findings indicate that the chikungunya outbreak in Salvador may not have conferred sufficient herd immunity to preclude epidemics in the near future. The unusually low frequency of symptomatic disease points to a need for further longitudinal studies to better investigate these findings.