Article
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru
Registro en:
LOPEZ, Katia et al. Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru. Plos One, v. 16, n. 1, e0243184, 14 p, Jan. 2021.
1932-6203
10.1371/journal.pone.0243184
Autor
Lopez, Kattya
Arriaga Gutiérrez, María Belen
Aliaga, Juan G.
Barreda, Nadia M.
Sanabria, Oswaldo M.
Huang, Chuan-Chin
Zhang, Zibiao
La Guardia, Ruth Garcia de
Lecca, Leonid
Carvalho, Ana Cristina Calçada
Kritski, Afrânio L.
Calderon, Roger I.
Resumen
This study was performed to investigate the role of dysglycemia on the genetic diversity of
Mycobacterium tuberculosis (MTB) among pulmonary tuberculosis (TB) patients to build
scientific evidence about the possible mechanisms of TB transmission. MTB isolates
obtained of patients affected by pulmonary tuberculosis from health care facilities of North
Lima—Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial
interspersed repetitive-unit -variable-number tandem repeats (MIRU-VNTR). Subsequently,
clinical and epidemiological characteristics were associated with clustering, lineages and
comorbid conditions. The analysis carried out 112 pulmonary TB patients from various
health centers in North Lima, 17 (15%) had diabetes mellitus (DM) and 33 (29%) had pre diabetes (PDM). Latin American-Mediterranean, Haarlem and Beijing were the most fre quent MTB lineages found in those patients. Previous TB (adjusted odds ratio [aOR] = 3.65;
95%CI: 1.32–17.81), age (aOR = 1.12; 95%CI: 1.03–1.45) and Beijing lineage (aOR = 3.53;
95%CI: 1.08–13.2) were associated with TB-DM comorbidity. Alcoholism (aOR = 2.92; 95%
CI: 1.10–8.28), age (aOR = 1.05; 95%CI: 1.03–1.12) and Haarlem lineage (aOR = 2.54;
95%CI: 1.04–6.51) were associated with TB-PDM comorbidity. Beijing and Haarlem line ages were independently associated with TB-DM and TB-PDM comorbidities, respectively.
Although these findings may be surprising, we must be cautious to suggest that dysglycemia
could be associated with a highly clustering and predisposition of MTB lineages related to a
serious impact on the severity of TB disease, which requires further research.