Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.

Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.

dc.creatorAlmeida, Marcos Célio de
dc.creatorCardoso, Silvia Andrade
dc.creatorBarral Netto, Manoel
dc.date2012-07-13T20:02:37Z
dc.date2012-07-13T20:02:37Z
dc.date2003
dc.date.accessioned2023-09-26T20:31:29Z
dc.date.available2023-09-26T20:31:29Z
dc.identifierDE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003.
dc.identifier0020-7519
dc.identifierdoi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4163
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858786
dc.descriptionThe initial steps of Leishmania infection in humans are largely unknown. There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules. We show here that Leishmania (L.) chagasi infection avoids inducing proinflammatory molecules and has striking down modulating effects on human monocytes or macrophages. It does not induce CD54, interleukin (IL)-12 or tumour necrosis factor-alpha, potent proinflammatory cytokines and down modulates CD11b expression in monocytes. Lipopolysaccharide stimulated IL-12 (p40) levels, CD54 and HLA-DR expression are diminished in infected monocytes as well as interferon-gamma stimulated HLA-DR and HLA-ABC expression in infected macrophages. There is a negative correlation between CD54 and CD86 expression in both monocytes and macrophages. The depressed expression of class I and II molecules, absence of key proinflammatory cytokines and impaired expression of costimulatory molecules induced by L. chagasi could leave the immune system, at least in its initial phases in anergy or ignorance.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCostimulation
dc.subjectCD54
dc.subjectCD11b
dc.subjectCD86
dc.subjectCytokines
dc.subjectLeishmania
dc.subjectAntígenos CD80/metabolismo
dc.subjectLeishmania infantum/patogenicidade
dc.subjectLeishmaniose Visceral/imunologia
dc.subjectLeishmaniose Visceral/parasitologia
dc.subjectMacrófagos/parasitologia
dc.subjectMonócitos/parasitologia
dc.subjectAntígenos CD/imunologia
dc.subjectAntígenos CD11b/imunologia
dc.subjectAntígenos CD86
dc.subjectAdesão Celular
dc.subjectCélulas Cultivadas
dc.subjectCitocinas/imunologia
dc.subjectRegulação para Baixo
dc.subjectCitometria de Fluxo
dc.subjectAntígenos HLA/imunologia
dc.subjectMolécula 1 de Adesão Intercelular/imunologia
dc.subjectInterferon gama/farmacologia
dc.subjectLipopolissacarídeos/farmacologia
dc.subjectAtivação Linfocitária
dc.subjectMacrófagos/imunologia
dc.titleLeishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
dc.titleLeishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
dc.typeArticle


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