In silico and in vitro: identifying new drugs

dc.creatorPauli, Ivani
dc.creatorTimmers, Luis Fernando Saraiva Macedo
dc.creatorCaceres, Rafael Andrade
dc.creatorSoares, Milena Botelho Pereira
dc.creatorAzevedo Junior, Walter Filgueira de
dc.date2015-04-22T18:52:19Z
dc.date2015-04-22T18:52:19Z
dc.date2008
dc.date.accessioned2023-09-26T20:29:08Z
dc.date.available2023-09-26T20:29:08Z
dc.identifierPAULI, I. et al. In silico and in vitro: identifying new drugs. Current Drug Targets, v. 9, n. 12, p. 1054-1061, 2008.
dc.identifier1873-5592
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10114
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857944
dc.description: Drug development is a high cost and laborious process, requiring a number of tests until a drug is made available in the market. Therefore, the use of methods to screen large number of molecules with less cost is crucial for faster identification of hits and leads. One strategy to identify drug-like molecules is the search for molecules able to interfere with a protein function, since protein interactions control most biological processes. Ideally the use of in silico screenings would make drug development faster and less expensive. Currently, however, the confirmation of biological activity is still needed. Due to the complexity of the task of drug discovery, an integrated and multi-disciplinary approach is ultimately required. Here we discuss examples of drugs developed through a combination of in silico and in vitro strategies. The potential use of these methodologies for the identification of active compounds as well as for early toxicity and bioavailability is also reviewed
dc.formatapplication/pdf
dc.languagepor
dc.publisherBentham Science Publishers Ltd
dc.rightsopen access
dc.subjectProtein target
dc.subjectDrug development
dc.subjectIn silico screening
dc.subjectIn vitro screening, pharmacokinetics
dc.subjectDesenho de Drogas
dc.subjectPreparações Farmacêuticas/química
dc.subjectAnsiolíticos/química
dc.subjectAnsiolíticos/farmacocinética
dc.subjectAntidepressivos/química
dc.subjectAntidepressivos/farmacologia
dc.subjectInibidores da Protease HIV/química
dc.subjectInibidores da Protease HIV/farmacologia
dc.subjectTécnicas In Vitro
dc.subjectModelos Moleculares
dc.subjectProteínas/química
dc.subjectRelação Estrutura-Atividade
dc.titleIn silico and in vitro: identifying new drugs
dc.typeArticle


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