Article
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis
Registro en:
NEVES, Elizabeth de Souza et al. Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 757-760, Nov./Dec, 2012.
0037-8682
10.1590/S0037-86822012000600020
1678-9849
Autor
Neves, Elizabeth de Souza
Curi, André Luis Land
Albuquerque, Maira Cavalcanti de
Silva, Cassius Schnel Palhano
Silva, Laura Berriel da
Bueno, Wendy Fernandes
Amendoeira, Maria Regina dos Reis
Almeida, Maria da Glória Bonecini de
Fernandes, Octavio
Resumen
A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of
infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis
in acute toxoplasmosis. Methods: A case-control study was conducted among 30 patients and 90 controls. Results: Although statistical associations were not
confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. Conclusions:
Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.