In 14 autistic boys, aged 6 14 years, free of drug treatment, with relatively intact verbal functions andwithout severe or moderate mental retardation (I.Q. 91.4±22.8), intermittent photic stimulation at 11 fixed frequencies of 3 24 Hz revealed latent deficiency of the right hemisphere in the photic driving reactivity, predominantly at the fast alpha and beta frequencies of stimulation. The left-side prevalence was observed: 1) in the total number of driving peaks evaluated for the first four harmonics in the EEG spectra of 14 cortical areas and 2) in the driving amplitude in the spectra of the 2 occipital areas. As compared to 21 normally developing boys matched on age who did not show interhemispheric asymmetry in the driving reactivity, the autistic patients had significantly lower driving characteristics only in the right hemisphere. There were nosignificant differences between the autistic and control groups in the spontaneous EEG spectra of theoccipital areas in the resting state.