Article
Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region
Registro en:
GIOVANETTI, Marta et al. Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region. Cell Reports, v. 30, p. 2275-2283, Feb. 2020.
2211-1247
10.1016/j.celrep.2020.01.085
2211-1247
Autor
Giovanetti, Marta
Faria, Nuno Rodrigues
Lourenço, José
Jesus, Jaqueline Goes de
Xavier, Joilson
Claro, Ingra Morales
Kraemer, Moritz U. G.
Fonseca, Vagner
Dellicour, Simon
Thézé, Julien
Salles, Flavia da Silva
Gräf, Tiago
Silveira, Paola Paz
Nascimento, Valdinete Alves do
Souza, Victor Costa de
Iani, Felipe Campos de Melo
Martins, Emerson Augusto Castilho
Cruz, Laura Nogueira
Wallau, Gabriel
Fabri, Allison
Levy, Flávia
Quick, Joshua
Azevedo, Vasco de
Aguiar, Renato Santana
Oliveira, Tulio de
Menezes, Camila Bôtto de
Castilho, Marcia da Costa
Terra, Tirza Matos
Silva, Marineide Souza da
Filippis, Ana Maria Bispo de
Abreu, Andre Luiz de
Oliveira, Wanderson Kleber
Croda, Julio
Melo, Carlos Frederico Campelo de Albuquerque e
Nunes, Marcio R. T.
Sabino, Ester Cerdeira
Loman, Nicholas
Naveca, Felipe Gomes
Pybus, Oliver G.
Alcantara, Luiz Carlos
Resumen
Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.