Estudo prospectivo de gestantes e seus bebês com risco de transmissão de toxoplasmose congênita em município do Rio Grande do Sul

Prospective study of pregnants and babies with risk of congenital toxoplasmosis in municipal district of Rio Grande do Sul

dc.creatorSpalding, Silvia Maria
dc.creatorAmendoeira, Maria Regina Reis
dc.creatorRibeiro, Luis Carlos
dc.creatorSilveira, Cláudio
dc.creatorGarcia, Aparecida Gomes Pinto
dc.creatorCamillo-Moura, Léa
dc.date2011-11-01T16:37:05Z
dc.date2011-11-01T16:37:05Z
dc.date2003
dc.date.accessioned2023-09-26T20:22:04Z
dc.date.available2023-09-26T20:22:04Z
dc.identifierSPALDING, Silvia Maria et al. Estudo prospectivo de gestantes e seus bebês com risco de transmissão de toxoplasmose congênita em município do Rio Grande do Sul. Revista da Sociedade Brasileira de Medicina Tropical, Brasília, DF, v. 36, n. 4, p. 483-491, jul./ago. 2003.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3298
dc.identifier10.1590/S0037-86822003000400009
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855286
dc.descriptionA população estudada foi composta por 2.126 gestantes atendidas em unidades do Sistema Único de Saúde da região noroeste do Estado do Rio Grande do Sul. Após o screening sorológico inicial ocorreu o acompanhamento das gestantes, durante o pré-natal, e de seus bebês. Foram realizadas dosagens de IgG, IgM, IgA, Avidez de IgG, inoculação em camundongos, PCR e coleta de placenta e de cordões umbilicais para realizar a técnica de imuno-histoquímica além de avaliações clínicas. Das gestantes avaliadas, 74,5% eram IgG reagentes e 3,6% IgM reagentes. Nas avaliações oftalmológicas, foi observada lesão em dez gestantes e uma criança apresentou lesões oftalmológicas e calcificações cerebrais. A presença de IgM específico anti-T.gondii, durante toda a gestação não caracterizou a fase aguda recente da infecção, fazendo-se necessária a realização de testes complementares. Ressalta-se a importância do acompanhamento de neonatos de mães com sorologia compatível com a infecção mesmo sem sinais e sintomas sugestivos de toxoplasmose congênita.
dc.descriptionThis study followed up 2,126 pregnant women cared for at SUS day-care clinics (Public Health Insurance System) of the northwest of the State of Rio Grande do Sul, Brazil. After serological screening we performed a follow up of all pregnant women and their babies. Serologic tests included: IgG, IgM, IgA and IgG avidity levels, mice inoculation and polymerase chain reaction (PCR) also placentas and umbilical materials were tested using immunoperoxidase as well as clinical evaluation. Of all the pregnant women screened, 74.5% were reactive to toxoplasmosis, and 3.6% presented IgM seropositivity. At ophthalmic evaluation ten women had ocular lesions and one infant presented eye lesions and brain calcification. The presence of anti-T.gondii specific IgM throughout the entire pregnancy did not characterize acute phase infection, for this, complementary tests were necessary. The importance is underscored for attendance of the newborn of mothers presenting serology compatible with this infection even in the absence of signs and symptoms of congenital toxoplasmosis.
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dc.rightsopen access
dc.subjectToxoplasmose congênita
dc.subjectTransmissão
dc.subjectAcompanhamento
dc.subjectSorologia
dc.subjectCongenital toxoplasmosis
dc.subjectTransmission
dc.subjectAttendance
dc.subjectSerology
dc.subjectToxoplasmose - epidemiologia
dc.subjectComplicações Parasitárias na Gravidez - epidemiologia
dc.subjectImunoglobulinas - sangue
dc.subjectAnticorpos Antiprotozoários - sangue
dc.subjectToxoplasmose - diagnóstico
dc.subjectToxoplasmose - quimioterapia
dc.subjectToxoplasmose - transmissão
dc.subjectComplicações Parasitárias na Gravidez - sangue
dc.subjectToxoplasmose Congênita - diagnóstico
dc.subjectToxoplasmose Congênita - epidemiologia
dc.subjectToxoplasmose Congênita - prevenção & controle
dc.subjectEstudos Soroepidemiológicos
dc.subjectEstudos de Casos e Controles
dc.subjectHumanos
dc.subjectFeminino
dc.subjectGravidez
dc.subjectRecém-Nascido
dc.subjectLactente
dc.titleEstudo prospectivo de gestantes e seus bebês com risco de transmissão de toxoplasmose congênita em município do Rio Grande do Sul
dc.titleProspective study of pregnants and babies with risk of congenital toxoplasmosis in municipal district of Rio Grande do Sul
dc.typeArticle


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