Article
The Growth of Brown Adipose Tissue in Cold-acclimatized Rats after Depletion of Mast Cell Histamine by Compound 48/80
Registro en:
DALÓ, Nelson L.; LÓPEZ-ORTEGA, Aura A.; MOUSSATCHÉ, Haity. The Growth of Brown Adipose Tissue in Cold-acclimatized Rats after Depletion of Mast Cell Histamine by Compound 48/80. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 83, n. 2, p. 215-217, Mar./Apr. 1998.
0074-0276
10.1590/S0074-02761998000200016
1678-8060
Autor
Daló, Nelson L.
López-Ortega, Aura A.
Moussatché*, Haity
Resumen
Cold acclimatization (4-5°C) is accompanied by 2-3 fold increase of brown adipose tissue (BAT).
This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintained at room temperature (28 ± 2°C) the BAT histamine content was 23.4 ± 5.9 (mean ± SD) µg/g of
tissue and cold acclimatization (5±1°C) produced a significant increase of BAT weight, but reduced the
histamine content to 8.4 ± 1.9 µg/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold
acclimatized rats could be due to a fast rate of amine utilization; alternatively an altered synthesis or
storage process may occur during acclimatization.