Article
Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
Registro en:
COSTA, Jaline Cabral da Costa et al. Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses. Viruses, v. 14, 1477, p. 1 - 10, July 2022.
1999-4915
10.3390/v14071477
Autor
Costa, Jaline Cabral da
Siqueira, Marilda Mendonça
Brown, David
Lopes, Jonathan Oliveira
Costa, Braulia Caetano da
Gama, Eric Lopes
Oliveira, Maria de Lourdes Aguiar
Resumen
Worldwide, infections by influenza viruses are considered a major public health challenge.
In this study, influenza B vaccine mismatches and clinical aspects of Victoria and Yamagata infections
in Brazil were assessed. Clinical samples were collected from patients suspected of influenza infection.
In addition, sociodemographic, clinical, and epidemiological information were collected by the
epidemiological surveillance teams. Influenza B lineages were determined by real-time RT-PCR
and/or Sanger sequencing. In addition, putative phylogeny–trait associations were assessed by
using the BaTS program after phylogenetic reconstruction by a Bayesian Markov Chain Monte Carlo
method (BEAST software package). Over 2010–2020, B/Victoria and B/Yamagata-like lineages cocirculated
in almost all seasonal epidemics, with B/Victoria predominance in most years. Vaccine
mismatches between circulating viruses and the trivalent vaccine strains occurred in five of the eleven
seasons (45.5%). No significant differences were identified in clinical presentation or disease severity
caused by both strains, but subjects infected by B/Victoria-like viruses were significantly younger
than their B/Yamagata-like counterparts (16.7 vs. 31.4 years, p < 0.001). This study contributes to a
better understanding of the circulation patterns and clinical outcomes of B/Victoria- and B/Yamagatalike
lineages in Brazil and advocate for the inclusion of a quadrivalent vaccine in the scope of the
Brazilian National Immunization Program.