Article
The genomic impact of european colonization of the americas
Registro en:
ONGARO, Linda et al. The genomic impact of european colonization of the americas. Current Biology, v. 29, p. 1-18, 2019.
1879-0445
10.1016/j.cub.2019.09.076
Autor
Ongaro, Linda
Scliar, Marilia O.
Flores, Rodrigo
Raveane, Alessandro
Marnetto, Davide
Sarno, Stefania
Gnecchi-Ruscone, Guido A.
Alarcón-Riquelme, Marta E.
Patin, Etienne
Wangkumhang, Pongsakorn
Hellenthal, Garrett
Santos, Miguel Gonzalez
King, Roy J.
Kouvatsi, Anastasia
Balanovsky, Oleg
Balanovska, Elena
Atramentova, Lubov
Turdikulova, Shahlo
Mastana, Sarabjit
Marjanovic, Damir
Mulahasanovic, Lejla
Leskovac, Andreja
Costa, Maria F. Lima
Pereira, Alexandre C.
Barreto, Mauricio L.
Horta, Bernardo L.
Mabunda, Nedio
May, Celia A.
Moreno-Estrada, Andres
Achilli, Alessandro
Olivieri, Anna
Semino, Ornella
Tambets, Kristiina
Kivisild, Toomas
Luiselli, Donata
Torroni, Antonio
Capelli, Cristian
Santos, Eduardo Tarazona
Metspalu, Mait
Pagani, Luca
Montinaro, Francesco
Resumen
The Italian Ministry of Education.
University and Research (MIUR).
Dipartimenti di Eccellenza Program.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’,.
University of Pavia.
Fondazione Cariplo.
European Union through the European Regional Development Fund.
Estonian Research Council.
Institutional Research Funding.
Estonian Ministry of Education and Research.
European Union through Horizon.
Russian Ministry of Science and Higher Education for the Research Centre for Medical Genetics.
Vavilov Institute of General Genetics . The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa.