Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines

dc.creatorReis, Débora C.
dc.creatorPinto, Mauro C. X.
dc.creatorSouza-Fagundes, Elaine M.
dc.creatorRocha, Lucas F.
dc.creatorPereira, Valéria R. A.
dc.creatorMelo, Cristiane M. L.
dc.creatorBeraldo, Heloisa
dc.date2018-12-27T14:38:10Z
dc.date2018-12-27T14:38:10Z
dc.date2011
dc.date.accessioned2023-09-26T20:18:24Z
dc.date.available2023-09-26T20:18:24Z
dc.identifierREIS, Débora C. et al. Investigation on the Pharmacological Profile of Antimony(III) Complexes with Hydroxyquinoline Derivatives: Anti-Trypanosomal Activity and Cytotoxicity against Human Leukemia Cell Lines. BioMetals, v. 24, n. 4, p. 595–601, 1 ago. 2011.
dc.identifier1572-8773
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30796
dc.identifier10.1007/s10534-011-9407-8
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853829
dc.descriptionCNPq and INCT-INOFAR
dc.descriptionComplexes [Sb(QN)(2)Cl] (1), [Sb(QC)(2)Cl] (2) and [Sb(QI)(2)Cl] (3) were obtained with 8-hydroxyquinoline (HQN), 5-chloro-8-hydroxyquinoline (HQC) and 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, HQI). The quinoline derivatives and their antimony(III) complexes were evaluated for their anti-trypanosomal activity as well as for their cytotoxicity against HL-60 and Jurkat human leukemia cell lines. Upon coordination to antimony(III) the anti-trypanosomal activity of HQC and HQI increases, the highest improvement being observed for complex (3), which was the most active among all studied compounds against both epimastigote and trypomastigote forms of Trypanosoma cruzi. All quinoline derivatives proved to be cytotoxic against both leukemia cell lineages. Upon coordination to antimony(III) the cytotoxicity of HQN improved against Jurkat leukemia cells. While SbCl(3) proved to be cytotoxic against HL-60 cells, it was not active against Jurkat cells. However, its coordination to the quinoline derivatives resulted in complexes with significant cytotoxicity against Jurkat cells.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subject8-Hydroxyquinoline
dc.subject5-Chloro-8- hydroxyquinoline
dc.subject5-Chloro-7-iodo-8- hydroxyquinoline (clioquinol)
dc.subjectAntimony(III) complexes
dc.subjectCytotoxicity
dc.subjectAnti-trypanosomal
dc.subjectAnimais
dc.subjectAntimônio / Química
dc.subjectAntineoplásicos / síntese química
dc.subjectAntineoplásicos / química
dc.subjectAntineoplásicos / farmacologia
dc.subjectAgentes Antiprotozoários / síntese química
dc.subjectAgentes Antiprotozoários / química
dc.subjectAgentes Antiprotozoários / Farmacologia
dc.subjectLinha Celular , Tumor
dc.subjectProliferação Celular / efeitos de drogas
dc.subjectEnsaios de Rastreio de Fármacos Antitumorais
dc.subjectCélulas HL-60
dc.subjectHumanos
dc.subjectHidroxiquinolinas / química
dc.subjectMasculino
dc.subjectRatos
dc.subjectRatos, endogâmicos BALB C
dc.subjectCompostos Organometálicos / síntese química
dc.subjectCompostos Organometálicos / química
dc.subjectCompostos Organometálicos / Farmacologia
dc.subjectTestes de Sensibilidade Parasitária
dc.subjectBaço / citologia
dc.subjectBaço / efeitos de drogas
dc.subjectRelação Estrutura- Atividade
dc.subjectTrypanosoma cruzi / efeitos de drogas
dc.subjectTrypanosoma cruzi / crescimento & desenvolvimento
dc.titleInvestigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines
dc.typeArticle


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