Article
Real-Time Genomic Surveillance during the 2021 Re-Emergence of the Yellow Fever Virus in Rio Grande do Sul State, Brazil
Registro en:
ANDRADE, Miguel de S. et al. Real-Time Genomic Surveillance during the 2021 Re-Emergence of the Yellow Fever Virus in Rio Grande do Sul State, Brazil. Viruses, v. 13, 1976, p. 1 - 12, Oct. 2021.
1999-4915
10.3390/v13101976
Autor
Andrade, Miguel de S.
Campos, Fabrício S.
Campos, Aline A. S.
Abreu, Filipe Vieira Santos de
Melo, Fernando L.
Sevá, Anaiá da
Cardoso, Jader da C.
Santos, Edmilson dos
Born, Lucas C.
Silva, Cláudia M. D. da
Müller, Nicolas F. D.
Oliveira, Cirilo H. de
Silva, Alex J. J. da
Simonini-Teixeira, Danilo
Valle, Sofía Bernal
Mares-Guia, Maria A. M. M.
Albuquerque, George R.
Romano, Alessandro P. M.
Franco, Ana C.
Ribeiro, Bergmann M.
Roche, Paulo M.
Almeida, Marco A. B. de
Resumen
The 2021 re-emergence of yellow fever in non-human primates in the state of Rio Grande
do Sul (RS), southernmost Brazil, resulted in the death of many howler monkeys (genus Alouatta)
and led the state to declare a Public Health Emergency of State Importance, despite no human
cases reported. In this study, near-complete genomes of yellow fever virus (YFV) recovered from
the outbreak were sequenced and examined aiming at a better understanding of the phylogenetic
relationships and the spatio-temporal dynamics of the virus distribution. Our results suggest that the
most likely sequence of events involved the reintroduction of YFV from the state of São Paulo to RS
through the states of Paraná and Santa Catarina, by the end of 2020. These findings reinforce the role
of genomic surveillance in determining the pathways of distribution of the virus and in providing
references for the implementation of preventive measures for populations in high risk areas.