CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.

dc.creatorCampanelli, Ana Paula
dc.creatorRoselino, Ana Maria Ferreira
dc.creatorCavassani, Karen Angélica
dc.creatorPereira, Marcelo de Souza Fernandes
dc.creatorMortara, Renato Arruda
dc.creatorBrodskyn, Claudia Ida
dc.creatorGonçalves, Heitor de Sá
dc.creatorBelkaid, Yasmine
dc.creatorBarral Netto, Manoel
dc.creatorBarral, Aldina Maria Prado
dc.creatorSilva, João Santana da
dc.date2014-03-17T18:36:18Z
dc.date2014-03-17T18:36:18Z
dc.date2006
dc.date.accessioned2023-09-26T20:11:08Z
dc.date.available2023-09-26T20:11:08Z
dc.identifierCAMPANELLI, A. P. et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, v. 193, n. 9, p. 1313–1322, 2006.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7413
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850744
dc.descriptionEndogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil, and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible involvement of Treg cells in the control of the immune response in human skin lesions caused by L. viannia braziliensis infection. We show that functional Treg cells can be found in skin lesions of patients with CL. These cells express phenotypic markers of Treg cells—such as CD25, cytotoxic T lymphocyte–associated antigen 4, Foxp3, and glucocorticoid-induced tumor necrosis factor receptor—and are able to produce large amounts of interleukin-10 and transforming growth factor–b. Furthermore, CD4+CD25+ T cells derived from the skin lesions of 4 of 6 patients with CL significantly suppressed in vitro the phytohemagglutinin-inducedproliferative T cell responses of allogeneic peripheral-blood mononuclear cells (PBMCs) from healthy control subjects at a ratio of 1 Treg cell to 10 allogeneic PBMCs. These findings suggest that functional Treg cells accumulate at sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functions
dc.formatapplication/pdf
dc.languageeng
dc.publisherthe Infectious Diseases Society of America.
dc.rightsopen access
dc.subjectAntígenos CD4/análise
dc.subjectLeishmania braziliensis
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectReceptores de Interleucina-2/análise
dc.subjectPele/imunologia
dc.subjectLinfócitos T Reguladores/imunologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAnimais
dc.subjectQuimiocinas CC/metabolismo
dc.subjectCriança
dc.subjectFeminino
dc.subjectFatores de Transcrição Forkhead/metabolismo
dc.subjectHumanos
dc.subjectImunossupressão
dc.subjectInterleucina-10/metabolismo
dc.subjectLeishmaniose Cutânea/patologia
dc.subjectAtivação Linfocitária
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectFenótipo
dc.subjectReceptores CCR4
dc.subjectReceptores de Quimiocinas/metabolismo
dc.subjectPele/microbiologia
dc.subjectPele/patologia
dc.subjectLinfócitos T Reguladores/citologia
dc.subjectFator de Crescimento Transformador beta/metabolismo
dc.titleCD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
dc.typeArticle


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