SARS-CoV-2’s Variants of Concern: A Brief Characterization

dc.creatorScovino, Aline Miranda
dc.creatorDahab, Elizabeth Chen
dc.creatorVieira, Gustavo Fioravanti
dc.creatorLima, Leonardo Freire de
dc.creatorLima, Celio Geraldo Freire de
dc.creatorMorrto, Alexandre
dc.date2023-01-13T12:49:57Z
dc.date2023-01-13T12:49:57Z
dc.date2022
dc.date.accessioned2023-09-26T20:11:04Z
dc.date.available2023-09-26T20:11:04Z
dc.identifierSCOVINO, Aline Miranda et al. SARS-CoV-2’s Variants of Concern: A Brief Characterization. Frontiers in Immunology, v. 13, 834098, p. 1-8, July 2022.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56454
dc.identifier10.3389/fimmu.2022.834098
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850712
dc.descriptionThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disclose the variants of concern (VOC) including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P1), Delta (B.1.617.2), and Omicron (B.1.1.529). Its spike protein (S) present on the surface of the virus is recognized by the host cell receptor, the angiotensin-2 converting enzyme (ACE2) which promotes their entry into the cell. The mutations presented by VOCs are found in RBD and the N-terminal region of S protein. Therefore, mutations occurring in RBD can modify the biological and immunogenic characteristics of the virus, such as modifying the spike affinity for ACE2, increasing the virus transmissibility, or conferring the ability to escape the immune responses. The raise of a potential new SARS-CoV-2 variant capable of evading the host defenses at the same time maintaining its fitness justifies the importance of continued genetic monitoring of the pandemic coronavirus.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectVacinação
dc.subjectFuga imune viral
dc.subjectVariantes do SARS-CoV-2
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectVaccination
dc.subjectViral immune escape
dc.subjectSARS-CoV-2 variants
dc.titleSARS-CoV-2’s Variants of Concern: A Brief Characterization
dc.typeArticle


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