Article
Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
Registro en:
SILVA, Icaro Bonyek et al. Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms. Frontiers in Endocrinology, v. 13, p. 1-9, 2022.
1664-2392
10.3389/fendo.2022.896378
Autor
Silva, Icaro Bonyek
Silva, Thiago Cerqueira
Nunes, Sara
Machado, Antônio Fernando Araújo
Cruz, Márrcio Rivison Silva
Pereira, Blenda
Estrela, Leilane
Silva, Jéssica
Isis, Ananda
Barral, Aldina
Oliveira, Pablo Rafael Silveira
Khouri, Ricardo
Serezani, C. Henrique
Brodskyn, Cláudia
Caldas, Juliana Ribeiro
Barral Netto, Manoel
Boaventura, Viviane
Tavares, Natalia Machado
Resumen
Inova Fiocruz – Fundação Oswaldo Cruz. Coordenação de Aperfeiçoamento de Pessoal da Nível Superior - Brésil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Projeto de Pesquisa do Estado da Bahia (FAPESB) Aims: Pre-existing conditions, such as age, hypertension, obesity, and diabetes, constitute known risk factors for severe COVID-19. However, the impact of prediabetes mellitus (PDM) on COVID-19 severity is less clear. This study aimed to evaluate the influence of PDM in the acute and long-term phases of COVID-19. Materials and methods: We compared inflammatory mediators, laboratory and clinical parameters and symptoms in COVID-19 patients with prediabetes (PDM) and without diabetes (NDM) during the acute phase of infection and at three months post-hospitalization. Results: Patients with PDM had longer hospital stays and required intensive care unit admission more frequently than NDM. Upon hospitalization, PDM patients exhibited higher serum levels of interleukin 6 (IL-6), which is related to reduced partial pressure of oxygen (PaO2) in arterial blood, oxygen saturation (SpO2) and increased COVID-19 severity. However, at three months after discharge, those with PDM did not exhibit significant alterations in laboratory parameters or residual symptoms; however, PDM was observed to influence the profile of reported symptoms. Conclusions: PDM seems to be associated with increased risk of severe COVID-19, as well as higher serum levels of IL-6, which may constitute a potential biomarker of severe COVID-19 risk in affected patients. Furthermore, while PDM correlated with more severe acute-phase COVID-19, no long-term worsening of sequelae was observed.
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