Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface

dc.creatorClain, Elodie
dc.creatorSinigaglia, Laura
dc.creatorKoishi, Andrea Cristine
dc.creatorGorgette, Olivier
dc.creatorGadea, Gilles
dc.creatorViranaicken, Wildriss
dc.creatorKrejbich-Trotot, Pascale
dc.creatorMavingui, Patrick
dc.creatorDesprès, Philippe
dc.creatorSantos, Claudia Nunes Duarte dos
dc.creatorGuiraud, Pascale
dc.creatorJouvenet, Nolwenn
dc.creatorEl-Kalamouni, Chaker
dc.date2019-03-01T19:50:35Z
dc.date2019-03-01T19:50:35Z
dc.date2018
dc.date.accessioned2023-09-26T20:08:58Z
dc.date.available2023-09-26T20:08:58Z
dc.identifierCLAIN, Elodie et al. Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface. Scientific Reports, v. 8, n. 10856, p. 1-12, 2018.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31953
dc.identifier10.1038/s41598-018-29183-2
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849743
dc.descriptionThe mosquito-borne Zika virus (ZIKV) belongs to the flavivirus genus of the Flaviviridae family. Contemporary epidemic strains of ZIKV are associated with congenital malformations in infants, including microcephaly, as well as Guillain-Barré syndrome in adults. A risk of human-to-human transmission of ZIKV is also well documented. A worldwide research effort has been undertaken to identify safe and effective strategies to prevent or treat ZIKV infection. We show here that extract from Aphloia theiformis, an edible endemic plant from Indian Ocean islands, exerts a potent antiviral effect against ZIKV strains of African and Asian lineages, including epidemic strains. The antiviral effect of A. theiformis extract was extended to clinical isolates of dengue virus (DENV) of the four serotypes in human hepatocytes. A. theiformis inhibited virus entry in host cells by acting directly on viral particles, thus impairing their attachment to the cell surface. Electron microscopic observations revealed that organization of ZIKV particles was severely affected by A. theiformis. We propose a model of antiviral action for A. theiformis against flaviviruses that highlights the potential of medicinal plants as promising sources of naturally-derived antiviral compounds to prevent ZIKV and DENV infections.
dc.formatapplication/pdf
dc.languagepor
dc.publisherNature Research
dc.rightsopen access
dc.subjectZika Virus Infection
dc.subjectMicrocephaly
dc.subjectAphloia theiformis
dc.subjectAntiviral Agents
dc.subjectDengue Virus
dc.subjectPlants, Medicinal
dc.subjectInfección por el Virus Zika
dc.subjectAntivirales
dc.subjectVirus del Dengue
dc.subjectPlantas Medicinales
dc.subjectInfecção pelo Zika virus
dc.subjectMicrocefalia
dc.subjectAntivirais
dc.subjectVírus da Dengue
dc.subjectPlantas Medicinais
dc.titleExtract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface
dc.typeArticle


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