Article
Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings
Registro en:
MAGIDSON, J. F. et al. Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings. AIDS and behavior, v. 20, n. 4, p. 699–709, 2016
1090-7165
10.1007/s10461-015-1142-7
Autor
Magidson, Jessica F
Li, Xin
Mimiaga, Matthew J
Moore, Ayana T
Srithanaviboonchai, Kriengkrai
Friedman, Ruth Khalili
Limbada, Mohammad
Hughes, James P
Cummings, Vanessa
Gaydos, Charlotte A
Elharrar, Vanessa
Celentano, David
Mayer, Kenneth H
Safren, Steven A
Resumen
Successful biomedical prevention/treatment-as-prevention (TasP) requires identifying individuals at greatest risk for transmitting HIV, including those with antiretroviral therapy (ART) nonadherence and/or 'amplified HIV transmission risk,' defined as condomless sex with HIV-uninfected/unknown-status partners when infectious (i.e., with detectable viremia or STI diagnosis according to Swiss criteria for infectiousness). This study recruited sexually-active, HIV-infected patients in Brazil, Thailand, and Zambia to examine correlates of ART nonadherence and 'amplified HIV transmission risk'. Lower alcohol use (OR = .71, p < .01) and higher health-related quality of life (OR = 1.10, p < .01) were associated with greater odds of ART adherence over and above region. Of those with viral load data available (in Brazil and Thailand only), 40 % met Swiss criteria for infectiousness, and 29 % had 'amplified HIV transmission risk.' MSM had almost three-fold (OR = 2.89, p < .001) increased odds of 'amplified HIV transmission risk' (vs. heterosexual men) over and above region. TasP efforts should consider psychosocial and contextual needs, particularly among MSM with detectable viremia. 2028-08-30