Abstract The dynamics of the internal migration is a crucial element in the composition of the workforce of a certain region, so its analysis contributes to the better understanding of labor markets and sociodemographic changes in a region. In order to characterize the most recent patterns of migratory flows of skilled and unskilled labor, census data are considered for the periods 1995-2000, 2005-2010 and 2010- 2015. The analysis considers different indicators that describe the intensity and relative concentration of interstate migration. Changes in migratory patterns are evident; a lower concentration of internal migration whose effect is more marked for unskilled labor. That is, it is observed that the number of states that play a preponderant role in the redistribution of labor in Mexico has increased. The relationship of domestic labor mobility is evident to the regional transformation as a result of new geographical patterns of location of investment, production and economic agglomeration.