Artigo
The mediating role of physical inactivity on the relationship between inflammation and artery thickness in prepubertal adolescents
Registro en:
Journal Of Pediatrics. New York: Mosby-elsevier, v. 166, n. 4, p. 924-929, 2015.
0022-3476
10.1016/j.jpeds.2014.12.057
WOS:000353385700029
4284333955006772
1329771683586073
1329771683586073
0000-0002-9645-1003
Autor
Cayres, Suziane Ungari [UNESP]
Lira, Fabio Santos de [UNESP]
Machado-Rodrigues, Aristides M.
Freitas Junior, Ismael Forte [UNESP]
Barbosa, Mauricio Fregonesi
Fernandes, Romulo Araujo [UNESP]
Resumen
Objective: To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice.Study design The sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 +/- 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity. Results: In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipoprotein-cholesterol (beta = -5.797 [-11.500 to -0.093]), femoral IMT (beta = 0.062 [0.008-0.116]), and the sum of femoral and carotid IMT (beta = 1.107 [0.223-1.919]), but only in the group without sports participation. Slopes of the crude linear regression were greater in the group without sports participation for femoral IMT (t = 2.621; P = .009) and the sum of femoral and carotid IMT (t = 2.876; P = .004) when compared with the group with sports participation. Conclusion: Independent of body fatness and biological maturation, inflammatory status was related to artery IMT and dyslipidemia in prepubertal adolescents, modulated by sport participation. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Universidade Estadual Paulista (UNESP), Instituto de Biociências (IBRC), Post-Graduate Program in Movement Sciences, Rio Claro, SP, Brasil Universidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia (FCT), Departamento de Educação Física, Laboratory of Investigation in Exercise - LIVE, Presidente Prudente, SP, Brasil Universidade Estadual Paulista (UNESP), Departamento de Educação Física, Immunometabolism Research Group, Presidente Prudente, SP, Brasil University of Coimbra, Faculty of Sport Sciences and Physical Education, Coimbra, Portugal Universidade Federal de São Paulo (UNIFESP), Program of Post-Graduate in Radiology, São Paulo, SP, Brasil Universidade Estadual Paulista (UNESP), Instituto de Biociências (IBRC), Post-Graduate Program in Movement Sciences, Rio Claro, SP, Brasil Universidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia (FCT), Departamento de Educação Física, Laboratory of Investigation in Exercise - LIVE, Presidente Prudente, SP, Brasil Universidade Estadual Paulista (UNESP), Departamento de Educação Física, Immunometabolism Research Group, Presidente Prudente, SP, Brasil FAPESP: 2013/06052-2 CNPq: 476295/2013-0