Artigo
Disperse Red 1 (textile dye) induces cytotoxic and genotoxic effects in mouse germ cells
Registro en:
Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 53, p. 75-81, 2015.
0890-6238
10.1016/j.reprotox.2015.04.002
WOS:000356318900012
5051118752980903
Autor
Fernandes, Fabio Henrique [UNESP]
Bustos-Obregon, Eduardo
Favero Salvadori, Daisy Maria [UNESP]
Resumen
Disperse Red 1 (DR1), which is widely used in the textile industry, is an azo dye that contributes to the toxicity and pollution of wastewater. To assess the toxic effects of DR1 on reproduction, sexually mature male mice (Mus musculus, strain CF-1) were orally (gavage) treated with single doses of the compound at 20, 100 and 500 mg/kg body weight. Testicular features and sperm parameters were evaluated 8.3, 16.6 and 24.9 days after treatments. In addition to testicular toxicity caused by the dye, the data clearly showed an increased frequency of sperm with abnormal morphology and decreased fertility. An increased amount of DNA damage was also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg. This study demonstrated the toxic and genotoxic effects of DR1, indicating the harmful activity of this dye on reproductive health. (C) 2015 Elsevier Inc. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Programa Latinoamericano de Salud Sexual y Reproductiva (PLISSER) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Univ Estadual Paulista, Biosci Inst, Dept Genet, BR-18618000 Botucatu, SP, Brazil Univ Chile, Sch Med, Santiago, Chile Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil Univ Estadual Paulista, Biosci Inst, Dept Genet, BR-18618000 Botucatu, SP, Brazil Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil FAPESP: 2008/10449-7