Artigo
The primate seahorse rhythm
Registro en:
Brain Research. Amsterdam: Elsevier Science Bv, v. 1613, p. 81-91, 2015.
0006-8993
10.1016/j.brainres.2015.03.054
WOS:000356553200008
Autor
Campos, Leila Maria Guissoni [UNESP]
Cruz-Rizzolo, Roelf Justino [UNESP]
Pinato, Luciana [UNESP]
Resumen
The main Zeitgeber, the day-night cycle, synchronizes the central oscillator which determines behaviors rhythms as sleep-wake behavior, body temperature, the regulation of hormone secretion, and the acquisition and processing of memory. Thus, actions such as acquisition, consolidation, and retrieval performed in the hippocampus are modulated by the circadian system and show a varied dependence on light and dark. To investigate changes in the hippocampus'cellular mechanism invoked by the day and night in a diurnal primate, this study analyzed the expression of PER2 and the calcium binding proteins (CaBPs) calbindin, calretinin and parvalbumin in the hippocampus of Sapajus apella, a diurnal primate, at two different time points, one during the day and one during the dark phase. The PER2 protein expression peaked at night in the antiphase described for the suprachiasmatic nucleus (SCN) of the same primate, indicating that hippocampal cells can present independent rhythmicity. This hippocampal rhythm was similar to that presented by diurnal but not nocturnal rodents. The CaBPs immunoreactivity also showed day/night variations in the cell number and in the cell morphology. Our findings provide evidence for the claim that the circadian regulation in the hippocampus may involve rhythms of PER2 and CaBPs expression that may contribute to the adaptation of this species in events and activities relevant to the respective periods. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Universidade Estadual Paulista, Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências de Marília Universidade Estadual Paulista, Departamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba FAPESP: 2011/51495-4