This study evaluated the corrosion kinetics and surface topography of Ti-6Al-4V alloy exposed to mouthwash solutions (0.12% chlorhexidine digluconate, 0.053% cetylpyridinium chloride and 3% hydrogen peroxide) compared to artificial saliva (pH 6.5) (control). Twenty Ti-6Al-4V alloy disks were used and divided into 4 groups (n = 5). For the electrochemical assay, standard tests as open circuit potential and electrochemical impedance spectroscopy (EIS) were applied at baseline, 7 and 14 days after immersion in the solutions. Scanning electron microscopy, atomic force microscopy and profilometry (average roughness - R-a) were used for surface characterization. Total weight loss of disks was calculated. Data were analyzed by ANOVA and Bonferroni's test (alpha = 0.05). Hydrogen peroxide generated the lowest polarization resistance (R-p) values for all periods (P < 0.05). For the capacitance (C-dl), similar results were observed among groups at baseline (P = 0.098). For the 7 and 14-day periods, hydrogen peroxide promoted the highest C-dl values (P < 0.0001). Hydrogen peroxide promoted expressive superficial changes and greater Ra values than the others (P < 0.0001). It could be concluded that solutions containing cetylpyridinium chloride and chlorhexidine digluconate might be the mouthwashes of choice during the post-operatory period of dental implants. However, hydrogen peroxide is counter-indicated in these situations. Further studies evaluating the dynamics of these solutions (tribocorrosion) and immersing the disks in daily cycles (two or three times a day) to mimic a clinical situation closest to the application of mouthwashes in the oral cavity are warranted to prove our results. (C) 2014 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Surg, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Integrated Clin, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Dent Mat & Prosthodont, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Prosthodont & Periodontol, BR-16015050 Sao Paulo, BrazilUniv Illinois, Coll Dent, Dept Restorat Dent, Chicago, IL 60612 USARush Univ, Med Ctr, Dept Orthoped Surg, Chicago, IL 60612 USAUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Surg, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Integrated Clin, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Dent Mat & Prosthodont, BR-16015050 Sao Paulo, BrazilUniv Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Prosthodont & Periodontol, BR-16015050 Sao Paulo, BrazilFAPESP: 11/20021-7CNPq: 120232/2013-8