Artigo
Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi
Registro en:
Malaria Journal. London: Biomed Central Ltd, v. 13, 10 p., 2014.
1475-2875
10.1186/1475-2875-13-203
WOS:000338951800002
WOS000338951800002.pdf
3577149748456880
0000-0001-8735-6090
Autor
Angella, Aline F. [UNESP]
Salgueiro, Patricia
Gil, Luiz H. S.
Vicente, Jose L.
Pinto, Joao
Ribolla, Paulo E. M. [UNESP]
Resumen
Background: Anopheles darlingi is the main malaria mosquito vector in the Amazonia region. In spite of being considered a riverine, forest-dwelling species, this mosquito is becoming more abundant in peri-urban areas, increasing malaria risk. This has been associated with human-driven environmental changes such as deforestation.Methods: Microsatellites were used to characterize A. darlingi from seven localities along the Madeira River, Rondonia (Brazil), collected in the early and late periods of the rainy season.Results: Two genetically distinct subpopulations were detected: one (subpopulation A) was associated with the late rainfall period and seems to be ecologically closer to the typical forest A. darlingi; the other (subpopulation B) was associated with the early rainfall period and is probably more adapted to drier conditions by exploiting permanent anthropogenic breeding sites. Results suggest also a pattern of asymmetric introgression, with more subpopulation A alleles introgressed into subpopulation B. Both subpopulations (and admixed mosquitoes) presented similar malaria infection rates, highlighting the potential for perennial malaria transmission in the region.Conclusions: The co-occurrence of two genetically distinct subpopulations of A. darlingi adapted to different periods of rainfall may promote a more perennial transmission of malaria throughout the year. These findings, in a context of strong environmental impact due to deforestation and dam construction, have serious implications for malaria epidemiology and control in the Amazonian region. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundacao para a Ciencia e Tecnologia (FCT) /Ministerio da Educacao e Ciencia (MEC) through the European Social Fund (ESF) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Univ Estadual Paulista Julio de Mesquita Neto, Inst Biociencias, Dept Parasitol, Botucatu, SP, Brazil Univ Nova Lisboa, Inst Higiene & Med Trop, UEI Parasitol Med, Ctr Malaria & Outras Doencas Tropicais, P-1200 Lisbon, Portugal IPEPATRO Inst Pesquisas Patologias Tropicais, Porto Velho, RO, Portugal Univ Estadual Paulista Julio de Mesquita Neto, Inst Biociencias, Dept Parasitol, Botucatu, SP, Brazil CAPES: capes128587311218103 Fundacao para a Ciencia e Tecnologia (FCT) /Ministerio da Educacao e Ciencia (MEC) through the European Social Fund (ESF)SFRH/BPD/72532/2010