Dissertação
Influência da interação medicamentosa no limiar de dor à pressão em indivíduos com osteoartrite de joelho
Fecha
2022-02-27Registro en:
Autor
Casonato, Natália Aparecida
Institución
Resumen
Objectives: To evaluate the influence of drug interaction on the pressure pain threshold
in a patient with knee osteoarthritis (KOA). Secondarily, we sought to assess the body
composition of subjects with KOA and its relationship with drug interaction. Two studies
were carried out: I: Association between drug interaction and pressure pain threshold in
individuals with knee osteoarthritis: A cross-sectional study; II: Is the presence of drug
interaction associated with a higher prevalence of fat mass in body composition in
individuals with knee osteoarthritis? Methods: Study I describes in detail the
methodology of Study II, where 80 participants with KOA aged over 40 years presented
the sample. Pain threshold assessment was performed using a pressure algometer, at four
points close to the knee. The Drugs.com database was used to check for possible
headaches between medications used for knee pain and other medications used by
participants with KOA. In addition, the Western Ontario and MacMaster Universities
Osteoarthritis Index Questionnaire (WOMAC) and Numerical Pain Scale (END) were
applied as complementary pain estimates. The secondary ones included data on body
composition, through the Dual-Energy X-Ray Absorptiometry (DXA) equipment. In
addition, the Pain Catastrophizing Scale and the Tampa Scale for Kinesiophobia were
applied as complementary pain estimates. Results: The results indicate that the presence
of drug interaction is associated with a lower pressure pain threshold, being linked to
advanced age and higher levels of pain reported by the END. In addition, it was
demonstrated that there is an association between the presence of associated diseases and
high levels of fat, associated with the presence of drug interactions, without association
with muscle and bone mass. Conclusion: The study tested that drug interaction is
associated with a decrease in pressure pain threshold and a greater presence of fat mass
in individuals with KOA.