article
Progressive myoclonic epilepsy type 8 due to CERS1 deficiency: a novel mutation with prominent ataxia
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Author
Godeiro Junior, Clécio de Oliveira
Vale, Thiago Cardoso
Afonso, Cintia Oliveira de Melo
Kok, Fernando
Pedroso, José Luiz
Barsottini, Orlando Graziani
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Abstract
Progressive myoclonic epilepsy (PME) is a heterogeneous groupof disorders characterized by myoclonus, tonic-clonic seizures,and progressive neurological dysfunction, including cognitiveimpairment and taxia. PME type 8 has recently been linked toa mutation inCERS1, the gene encoding ceramide synthase 1(Cers1), a transmembrane protein of the endoplasmic reticulumthat catalyzes the biosynthesis of C18-ceramides. Ceramides arethe precursors to complex sphingolipids, which are lipids with acommon sphingoid base (also termed long chain base) backbonethat plays an essential role in cell signaling, growth, proliferation,differentiation, and apoptosis. In the central nervous system, themost highly expressed ceramide synthase is Cers1, which is partic-ularly present in neurons of neocortex, hippocampus, and cere-bellum. Diminished levels of ceramides and sphingolipidscontaining very long-chain fatty acids have been associated withmany neurodegenerative disorders, including cerebellar Purkinjecell neurodegeneration. In addition, deficiency of Cers functionhave also been linked to accumulation of lipofuscin with ubiqui-tylated proteins in many brain regions.